Infectious syphilis mimicking neoplastic disease

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Abstract
Five patients who were initially evaluated for malignant neoplasms had infectious syphilis (1 primary, 2 secondaries, 2 secondaries with persistence of primary). Two patients were considered for radical surgery and 1 for extensive radiation and/or chemotherapy. In 4 patients an elevated routine admission VDRL [venereal disease research laboratory] test was the 1st indication of the correct diagnosis. Dark field examination is the most important laboratory test in the diagnosis of primary syphilis. VDRL and FTA-ABS [fluorescent treponemal antibody absorption] are most important in confirming secondary syphilis. Penicillin remains the drug of choice for therapy. At a time when the incidence of sexually transmitted diseases is increasing, it is extremely important to develop adequate educational programs for medical students and physicians.

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