Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

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Abstract
The effect of aldose reductase inhibitors such as sorbinil, alrestatin and quercitrin was studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver and red cells. None of the aldose reductase inhibitors were specific for aldose reductase. Fifty micromolar Sorbinil [50 .mu.M), besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.