TOXICITY AND ANTICANCER ACTIVITY OF A NEW TRIAZINE ANTI-FOLATE (NSC-127755)

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (5) , 1707-1715
Abstract
A new triazine folate antagonist, 3-chloro-4-[[4-[2-chloro-4-[4,6-diamino-2,2-dimethyl-s-triazin-1(2H)-yl]phenyl]butyl]] benzenesulfonyl fluoride compounded with ethanesulfonic acid (1:1) (NSC 127755), was highly active against 4 transplantable colon adenocarcinomas (36, 38, 10/A, 12/A) and the Dunning murine ovarian tumor M5076. Treatment schedule studies indicated that a prolonged time of exposure provided optimum antitumor activity for the compound. The combination of NSC 127755 plus 4-amino-1-[5-O-(1-oxohexadecyl)-.beta.-D-arabinofuranosyl]-2(1H)-pyrimidinone (palmO-ara-C, NSC 135962) had therapeutic synergism against grossly evident colon adenocarcinoma 36.