Nafcillin Concentration in Cerebrospinal Fluid During Treatment of Staphylococcal Infections

Publisher Website
Google Scholar
Abstract
The nafcillin concentration of simultaneous CSF and serum specimens from 9 patients being treated with parenteral nafcillin for staphylococcal infection were measured. Marked variations in the ratio of CSF/serum nafcillin concentration were observed. The concentration of nafcillin in the CSF was greater than the minimum lethal concentration (MLC) for Staphylococcus aureus in 8 of the 9 patients. In 5 patients with CSF pleocytosis, the nafcillin concentration was 3-100 times the MLC. These results support the recommendation to use nafcillin in doses of at least 100-200 mg/kg body wt per day for treatment of meningitis caused by S. aureus.