Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene
- 1 July 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5924) , 315-320
- https://doi.org/10.1038/304315a0
Abstract
Experimental insertion of a retrovirus into the germ line of mice resulted in an embryonic recessive lethal mutation. Integration of the proviral genome occurred at the 5'' end of the .alpha.1(I) collagen gene, leading to a complete transcriptional block. Developmental arrest of embryos homozygous at the mutated allele coincides with high expression of the gene in normal embryogenesis. Insertion mutagenesis by retroviruses may offer a general approach to the identification and isolation of genes which are transcriptionally active during mammalian development.Keywords
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