The Ultrastructure of Pancreatic Tissue from Duct-Ligated Rats Implanted into Anterior Chamber of Rat Eyes

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Abstract
Pancreatic tissue from rats with ligated pancreatic ducts was implanted into the anterior chamber of the eyes of diabetic and non-diabetic rats, and the ultrastructure of the implants studied afterwards at inervals ranging from 15 min to 4 weeks. During the first, avascular, stage, lasting for 2 days at most, serious damage to a number of the islet cells was noted. During the next, revascularization stage, the ultrastructure, especially in the 2–4-week-old implants, pointed to recovery and/or regeneration of islet cells; on the whole, both the β and α cells in the implants from the non-diabetic hosts showed a normal ultrastructure at this time, whereas in the implants from the diabetic hosts the β cells showed signs of heightened activity. The cells in the excretory ducts showed largely the same changes with the passage of time as the islet cells, but to a less pronounced degree. The ultrastructure of the duct cells at the end of a few weeks exhibited greater signs of activity in the implants from...