Fluoride Inhibition of Polymorphonuclear Leukocytes

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Abstract
Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 1.0 mM F- for O-2 generation, 1-C14 CO 2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of non-oxidative glucose metabolism. As the concentration of F- in the O- 2 generating system increased beyond 10 mM, a rise in production of O-2 anion occurred, peaking at 20 mM F-, followed by a rapid decline.