Methandrostenolone: Metabolism in the rabbit
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 9 (3) , 229-233
- https://doi.org/10.1007/bf03189646
Abstract
Methandrostenolone and the fully reduced metabolites 17α-methyl-5α-androstane-3β, 17β-diol and 17α-methyl-5β-androstane-3α, 17β-diol, the partially reduced and hydroxylated metabolites 16α, 17β-dihydroxy-17α-methyl-5β-androst-1-en-3-one and 16β,17β-dihy-droxy-17α-methyl-5β-androst-1-en-3-one, the monohydroxylated metabolites 6β, 17β-dihydroxy-17α-methyl-1,4-androstadien-3-one and 16β, 17β-dihydroxy-17α-methyl-1,4-androstadien-3-one, and the dihydroxylated metabolite 6β,16β, 17β-trihydroxy-17β-trihydroxy-17α-methyl-l,4-androstadien-3-one have been isolated and identified in the urine of rabbits orally dosed with methandrostenolone. C-16 Hydroxylated and dihydroxylated metabolites have not been previously reported from methandrostenolone. No evidence for epimerization at the C-17 position was observed in the rabbit.This publication has 18 references indexed in Scilit:
- Metabolism of 17α-methyltestosterone in the rabbit: C-6 and C-16 hydroxylated metabolitesSteroids, 1983
- Metabolism of 17α-methyl-5β-dihydrotestosterone in the rabbitSteroids, 1983
- Proton magnetic resonance spectra of 17ξ-Hydroxy-17ξ-methyl-5ξ-androstane C-3 ketone and c-3ξ alcohol isomers in chloroform-d and pyridine-d5Steroids, 1983
- Metabolism of 17α-methyl-5α-dihydrotestosterone in the rabbitSteroids, 1982
- Studies on anabolic steroids. The mass spectra of 17α-methyl-17β-hydroxy-1,4-androstadien-3-one (dianabol) and its metabolitesJournal of Mass Spectrometry, 1980
- Assignment of proton-decoupled carbon-13 spectra of complex molecules by using polarization transfer spectroscopy. A superior method to off-resonance decouplingJournal of the American Chemical Society, 1980
- The identification of 17α-hydroxy-17-methyl-1,4-androstadien-3-one as a metabolite of the anabolic steroid drug 17β-hydroxy-17-methyl-1,4-androstadien-3-one in manSteroids, 1971
- β-Side catalytic hydrogenation and the molecular structure of 17β-Hydroxy-1,4-Androstadien-3-One: p-bromophenol (1:1)Steroids, 1971
- Metabolism of 1-dehydroand rostanes in manSteroids, 1971
- In vivo metabolism of Δ, 17α-methyltestosterone in manSteroids, 1963