Increase in Serum Alkaline Phosphatase (S‐ALP) in Chronic Myelocytic Leukemia—Sign of Drug‐Induced Cholestasis?
- 12 January 1978
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 203 (1-6) , 93-94
- https://doi.org/10.1111/j.0954-6820.1978.tb14837.x
Abstract
In 4 patients with chronic myelocytic leukemia, a solitary rise in serum S-ALP was noted 2-12 mo. prior to death. All patients had received busulfan (Myleran) therapy for longer than 12 mo. (total dosage 1.0-2.4 g). The increase in S-ALP apparently was due to a cholestatic liver damage, possibly secondary to the busulfan treatment.This publication has 2 references indexed in Scilit:
- Unerwünschte Nebenwirkungen von BusulfanDeutsche Medizinische Wochenschrift (1946), 1974
- Jaundice after treatment of leukemia with busulphan.BMJ, 1971