Genotyping errors: causes, consequences and solutions
Top Cited Papers
- 27 September 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 6 (11) , 847-859
- https://doi.org/10.1038/nrg1707
Abstract
Although genotyping errors affect most data and can markedly influence the biological conclusions of a study, they are too often neglected. Errors have various causes, but their occurrence and effect can be limited by considering these causes in the production and analysis of the data. Procedures that have been developed for dealing with errors in linkage studies, forensic analyses and non-invasive genotyping should be applied more broadly to any genetic study. We propose a protocol for estimating error rates and recommend that these measures be systemically reported to attest the reliability of published genotyping studies.Keywords
This publication has 106 references indexed in Scilit:
- micro‐checker: software for identifying and correcting genotyping errors in microsatellite dataMolecular Ecology Notes, 2004
- Increasing Power for Tests of Genetic Association in the Presence of Phenotype and/or Genotype Error by Use of Double-SamplingStatistical Applications in Genetics and Molecular Biology, 2004
- The power and promise of population genomics: from genotyping to genome typingNature Reviews Genetics, 2003
- Effects of genotyping errors, missing values and segregation distortion in molecular marker data on the construction of linkage mapsHeredity, 2003
- Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?Human Genetics, 2002
- Computational analysis of microarray dataNature Reviews Genetics, 2001
- Statistical confidence for likelihood‐based paternity inference in natural populationsMolecular Ecology, 1998
- Problems of reproducibility – does geologically ancient DNA survive in amber–preserved insects?Proceedings Of The Royal Society B-Biological Sciences, 1997
- The Effects of Genoiyping Errors and Interference on Estimation of Genetic DistanceHuman Heredity, 1997
- A Double Sampling Scheme for Estimating from Misclassified Multinomial Data with Applications to Sampling InspectionTechnometrics, 1972