Generalized Hypersensitivity Reaction and Visceral Arteritis with Fatal Outcome During Glibenclamide Therapy
- 1 September 1974
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 23 (9) , 739-742
- https://doi.org/10.2337/diab.23.9.739
Abstract
A severe generalized hypersensitivity reaction with toxic erythema, cholestatic jaundice and eosinophilia complicated by bronchopneumonia and renal failure with fatal outcome is described in a sixty-seven-year-old male diabetic patient treated with the recently introduced sulfonylurea, glibenclamide. Autopsy findings included the demonstration of a necrotizing angiitis with associated granulomatous changes in the spleen and kidneys.Keywords
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