The Stereochemistry of Organometallic Compounds. LXI. The Preparation of Quinazolines and Quinazolinones Involving Rhodium-Catalyzed Hydroformylation of Alkenyl Anilines
- 1 January 1994
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 47 (6) , 1061-1070
- https://doi.org/10.1071/ch9941061
Abstract
Rhodium-catalysed reactions of ortho-alkenylaminobenzylamines or benzamides with H2/CO give quinazolines and quinazolinones containing a fused alicyclic ring in excellent yields. Reactions of N- allyl derivatives give a single regioisomer. Reactions of but-3-enyl analogues give readily separable mixtures of pyrrolo and pyrido derivatives. Their 3-methylbut-3-enyl analogues give the pyrido derivatives (12) and (13) in reactions which show unusual diastereoselectivity.Keywords
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