-Lactamase stability of cefotaxime

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Abstract
Although a large number of β-lactamases have now been detected in various bacteria of clinical importance, broadly speaking all fall within three main classes. These are (1) enzymes which have a predominant activity against cephalosporins; (2) enzymes which are active against a wide range of penicillins and cephalosporins but which are inhibited by cloxacillin; and (3) those with a broad specificity including cloxacillin. Against these enzyme classes, cefotaxime joins cefuroxime and cefoxitin in being effectively resistant to destruction by all of them. The ability of various cephalosporins to penetrate to their targets is a crucial aspect of their properties. While not as effective in this respect as some cephalo-sporins, cefotaxime nevertheless penetrates well enough to give excellent MIC values in practice; and the resistance of the compound to β-lactamase destruction ensures that these excellent properties are maintained even with ampicillin resistant organisms.

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