Proton Nuclear Magnetic Resonance Spectroscopy of Plasma from Healthy Subjects and Patients with Cancer

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Abstract
To evaluate the ability of proton nuclear magnetic resonance (NMR) spectroscopy to indicate the presence or absence of malignant disease, we analyzed plasma samples from 104 patients with untreated cancer of various types and from 164 healthy controls. All specimens were coded with random numbers, and the investigators were blind to patient category. A statistically significant difference (P<0.001) was found between the mean (±SD) line widths in the plasma samples from the controls (39.1±6.7 Hz) and the line widths in plasma from the patients with cancer (35.2±6.4 Hz). However, the values showed considerable overlap between the two groups.