Studies on the Cytotoxic Effect of Enzyme Preparations

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Abstract
The cytotoxic effect of two enzyme preparations for wound treatment has been studied. Testing was performed partly in vitro (tissue culture), and partly in vivo (wound strength). Regarding Varidase®, it was established in vitro that the effect depended upon dosage and exposure time, and that proper dose and time increased growth rate in treated explants of heart muscle from chicken embryos. Both preparations were tested in vivo and at clinically recommended concentrations, Varidase increased wound strength, while Trypure® showed some decrease.

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