A Phase II Study of lntravesical Mitomycin C in the Treatment of Superficial Bladder Cancer
- 1 December 1983
- journal article
- Published by Wiley in British Journal of Urology
- Vol. 55 (6) , 676-679
- https://doi.org/10.1111/j.1464-410x.1983.tb03402.x
Abstract
Twenty-three patients with histologically proven superficial bladder cancer (Tis, Ta, T1) were treated with intravesical instillations of Mitomycin C at a dose of 20 mg in 20 ml of water 3 times weekly for 21 instillations. Seventeen patients (77%) showed complete disappearance of all known disease and a further 4 showed partial responses. In 8 patients toxic effects developed (thrombocytopaenia 1, chemical cystitis 2, skin rash 3, urinary tract infection 2). All resolved rapidly on stopping the treatment but were severe enough in 5 patients to prevent them from receiving a full course of treatment.Keywords
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