Late onset parkinsonian syndrome in Hallervorden-Spatz disease.
Open Access
- 1 December 1987
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 50 (12) , 1665-1668
- https://doi.org/10.1136/jnnp.50.12.1665
Abstract
Two siblings, from consanguineous parents, developed in their twenties a Parkinsonian syndrome. In the elder, the disease evolved for 13 years and the necropsic study was diagnostic of Hallervorden-Spatz disease. The younger sibling is severely affected after 12 years of the disorder. Several CT and one MR studies done in this patient during the last 4 years have been normal. Ultrastructural studies of the bone marrow histiocytes and blood lymphocytes disclosed peculiar inclusions. Bromocriptine in low doses proved to be a beneficial therapy for this patient.This publication has 7 references indexed in Scilit:
- Hallervorden‐Spatz disease: Cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidusAnnals of Neurology, 1985
- MR Imaging of Hallervorden-Spatz DiseaseJournal of Computer Assisted Tomography, 1985
- Late‐onset Hallervorden‐Spatz disease presenting as familial parkinsonismNeurology, 1985
- Sea‐blue histiocytes, lymphocytic cytosomes, movement disorder and 59 Fe‐uptake in basal gangliaNeurology, 1983
- Thyroid function in Parkinson diseaseNeurology, 1981
- Computed tomography in Hallervorden‐Spatz diseaseNeurology, 1980
- Hallervorden-Spatz SyndromeArchives of Neurology, 1974