Bence-Jones Proteins and Light Chains of Immunoglobulins

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Abstract
Role of the Light Chain in the Antibody-Combining SiteRecombination and affinity-labeling experiments have provided evidence that both heavy and light chains are required for antibody activity, a finding indicating that each chain contributes to the antigen-binding site.45 However, data derived from hapten-binding and viral neutralization studies indicate activity expressed individually by heavy chains and light chains, respectively,97 98 99 100 101 and suggest that this phenomenon depends, in part, on the fact that either chain can exist in the dimeric form.100 , 101 The postulation100 that each species in the dimer interacts in a manner analogous to the heavy-light chain interaction to form the antibody-combining . . .