A short, efficient chiral synthesis of a novel cholinergic channel activator, ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole], from (S)-pyroglutamic acid
- 10 April 1995
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 36 (15) , 2563-2566
- https://doi.org/10.1016/0040-4039(95)00340-i
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic ActivitiesJournal of Medicinal Chemistry, 1994
- Studies On Isoxazole Formation from Alkyl Carboxylic EstersSynthesis, 1994
- Amino acids. 7. A novel synthetic route to L-prolineThe Journal of Organic Chemistry, 1986
- Synthesis of meta,meta-bridged biaryls ([7.0]-metacyclophanes)via aryl-aryl coupling: factors affecting the cyclisationJournal of the Chemical Society, Perkin Transactions 1, 1983
- The preparation of 5-phenacylisoxazoles and 5-hydroxyphenyl-isoxazoles and -pyrazoles by the condensation of C(a)-dianions with ethyl benzoylacetate and methyl salicylateJournal of Heterocyclic Chemistry, 1982
- An improved synthesis of 3,5‐disubstituted isoxazoles and pyrazoles from C(α),O‐dilithiooximes and C(α),N‐dilithiophenylhydrazonesJournal of Heterocyclic Chemistry, 1980
- Preparation of Tri- and TetramethyleneisoxazolesJournal of Pharmaceutical Sciences, 1976
- The reactions of C(α),O-dilithiooximes, C(α),N-dilithiophenylhydrazones, and C(α),N,N-trilithiohydrazones with diethyl oxalate to give biisoxazoles, bipyrazoles, and pyridazonesJournal of Heterocyclic Chemistry, 1975
- New synthesis of isoxazoles from 1,4-dianions of oximes having an .alpha. hydrogen. Mass spectrometryThe Journal of Organic Chemistry, 1970