2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
- 4 July 2002
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 12 (15) , 2019-2022
- https://doi.org/10.1016/s0960-894x(02)00311-6
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targetsChemistry & Biology, 2001
- Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor XaJournal of Medicinal Chemistry, 2001
- A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site11Edited by D. ReesJournal of Molecular Biology, 2001
- Emerging therapeutic targets in oncology: urokinase-type plasminogen activator systemEmerging Therapeutic Targets, 1999
- Crystal Structure of the Catalytic Domain of Human Plasmin Complexed with StreptokinaseScience, 1998
- An Improved One-pot Procedure for the Synthesis of Alkynes from AldehydesSynlett, 1996
- Prevention of prostate‐cancer metastasis in vivo by a novel synthetic inhibitor of urokinase‐type plasminogen activator (uPA)International Journal of Cancer, 1995
- Urokinase‐Type Plasminogen Activator (uPA) and Its Receptor (CD87): A New Target in Tumor Invasion and MetastasisJournal of Obstetrics and Gynaecology Research, 1995
- Methanolysis of Dimethyl (1-Diazo-2-oxopropyl) Phosphonate: Generation of Dimethyl (Diazomethyl) Phosphonate and Reaction with Carbonyl CompoundsSynthetic Communications, 1989
- Antibodies to plasminogen activator inhibit human tumor metastasisCell, 1983