Lithium and the Pituitary-Thyroid Axis in Normal Subjects
- 1 August 1974
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 39 (2) , 383-385
- https://doi.org/10.1210/jcem-39-2-383
Abstract
Eight healthy volunteers were given lithium carbonate 600–900 mg daily for 3 weeks. No changes in the serum levels of triiodothyronine (T3), thyroxine (T4), T3-resin uptake and thyrotropin (TSH) were seen following lithium treatment. However, after stimulation with thyrotropin-releasing hormone (TRH) 200 fig intravenously a significantly decreased T3 response (p < 0.05) and a significantly increased TSH response (p ≤ 0.02) were found as compared to the results before lithium treatment. Since the T3 response was diminished in spite of increased TSH levels during TRH stimulation, it is assumed that lithium decreases the sensitivity of the thyroid gland to TSH as measured by T3 release.Keywords
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