EFFECT OF KETAMINE ON TRANSMISSION IN SYMPATHETIC GANGLIA
Open Access
- 1 April 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (4) , 371-375
- https://doi.org/10.1093/bja/52.4.371
Abstract
The effect of ketamine on sympathetic ganglion transmission has been studied using the guineapig isolated hypogastric nerve-vas deferens preparation. Ketamine produced a dose-dependent depression in the response to preganglionic stimulation (IC50, 2.05 × 10−4 mol litre−1). No change in the response to postganglionic stimulation was recorded. The anti-cholinergic activity of ketarnine was confirmed using the frog isolated rectus abdominis.Keywords
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