The action of alloxan and related compounds on alkaline phosphatase

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Abstract
Alloxan and related compounds were tested for inhibition of alkaline phosphatase in vitro, and in tissue sections using the Gomori technique. Alloxan, dialuric acid, l-methylalloxan and alloxantin were highly active inhibitors of alkaline phosphatase; isodialuric acid, alloxanic acid were weak inhibitors. Related compds. tested and found to cause no inhibition were mesoxalic acid, violuric acid, uracil, thio-uracil, barbiturates, allantoin, urea, and thiourea. The high inhibitory activity of the 4 ureides corresponds to the known diabetogenic activity of these compds. The inhibition has been demonstrated in the presence of blood, plasma, and in tissue sections. It is reversible, non-competitive, and un-affected by Mg.

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