Opsonic Activity in the Newborn: Role of Properdin
- 1 July 1973
- journal article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 52 (1) , 134-137
- https://doi.org/10.1542/peds.52.1.134
Abstract
Relative to pooled adult serum, most cord sera have normal or slightly diminished opsonic activity. Fifteen percent of the cord sera had markedly impaired opsonic power. This activity did not correlate with immunoglobulin or C3 levels but was associated with significantly subnormal concentrations of GBG, a component of the properdin system. The deficient opsonic activity of some cord serum is thus due to hypofunction of the alternate complement pathway.Keywords
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