β‐Adrenoceptor stimulating properties of para‐dimethylaminobenzaldehyde
Open Access
- 1 June 1970
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 39 (2) , 447-454
- https://doi.org/10.1111/j.1476-5381.1970.tb12907.x
Abstract
1 Studies on the various isolated tissues indicate that para-dimethylaminobenzaldehyde (DMAB) is a β-adrenoceptor stimulant. DMAB is antagonized by the β-adrenoceptor blocking agent, MJ 1999, but not by the α-adrenoceptor blocking agent, phentolamine. 2 A study of dose-response relationships suggests a competitive interaction between MJ 1999 and DMAB. 3 DMAB was about 122 times less potent than isoprenaline on the isolated guinea-pig tracheal preparation. The effects of DMAB on isolated rabbit atria were not only very weak, but were also very brief. On this tissue, DMAB was respectively 72,000 and 55,400 times less active than isoprenaline in producing positive chronotropic and inotropic effects. DMAB caused the relaxation of the guinea-pig taenia coli and the rabbit ileum. These actions were very weak in comparison with those of isoprenaline. 4 These results suggest that a compound (DMAB) structurally different from isoprenaline may mimic isoprenaline responses by stimulating β-adrenoceptors through different mechanisms.Keywords
This publication has 4 references indexed in Scilit:
- Structure-Activity Relationships in the Adrenergic-Blocking AgentsJournal of Pharmaceutical Sciences, 1969
- A new tracheal strip preparation for the evaluation of β-adrenergic activityJournal of Pharmacy and Pharmacology, 1968
- BLOCKADE OF THE BIOCHEMICAL CORRELATES OF CONTRACTION AND RELAXATION IN UTERINE AND INTESTINAL SMOOTH MUSCLE*Annals of the New York Academy of Sciences, 1967
- The nature of the adrenergic receptors of the trachea of the guinea-pigJournal of Pharmacy and Pharmacology, 1966