Effect of Neonatal Hydrocortisone on Corticosteroid Circadian Periodicity, Responsiveness to ACTH and Stress in Prepuberal and Adult Rats

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Abstract
500 µg hydrocortisone acetate was administered subcutaneously to 2-day-old male and female rats. Study of these animals at 30 days of age revealed virtual obliteration of the circadian periodicity of plasma corticosteroid levels, but preservation of normal adrenal responsiveness to ACTH and to the stresses of immobilization and etherization. Circadian periodicity was normal in both male and female animals studied at 80 days of age. The other cited parameters were tested only in male animals at this age, and again were found to be normal. These studies indicate (1) a dissociation between the effects of neonatal corticosteroid administration on corticosteroid periodicity and corticosteroid responsiveness to ACTH and stress; and (2) the lack of permanence of the effects on corticosteroid periodicity.

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