The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 35 (6) , 681-684
- https://doi.org/10.1007/bf00637608
Abstract
Administration of 12-mg doses of ivermectin (H2B1a) to 12 healthy volunteers in the form of tablets, capsules, and alcoholic oral solution showed the solution to have approximately twice the systemic availability as either of the solid forms, as evidence both by the maximum concentrations of drug attained in plasma and by the corresponding areas under the plasma concentration vs time curves. However, the two solid formulations showed similar systemic availability.Keywords
This publication has 6 references indexed in Scilit:
- Determination of ivermectin in human plasma and milk by high-performance liquid chromatography with fluorescence detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- Controlled Trial and Dose-Finding Study of Ivermectin for Treatment of OnchocerciasisThe Journal of Infectious Diseases, 1987
- Comparison of Ivermectin and Diethylcarbamazine in the Treatment of OnchocerciasisNew England Journal of Medicine, 1985
- Pharmacokinetics of Ivermectin Administered Intravenously to CattleJournal of Pharmaceutical Sciences, 1985
- The chemotherapy of onchocerciasis X.Pathogens and Global Health, 1985