Synthesis of a Novel Type of Chiral Bisphosphine Ligand (NORPHOS-7-NEt2) with an Amino Group for Neighboring Participation in Asymmetric Allylic Alkylation
- 1 January 1998
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1998 (01) , 45-46
- https://doi.org/10.1055/s-1998-1578
Abstract
A new chiral bisphosphine ligand, NORPHOS-7-NEt2, with an amino group has been prepared. It has been applied to the Pd-catalyzed asymmetric allylic alkylation of rac-(E)-diphenyl-2-propenyl pivalate upon using (2S,3S,7R)-NORPHOS-7-NEt2 (1) (M-Chirality) having an amino group on the ligand, the same absolute configuration product was obtained as compared to using (2R,3R)-NORPHOS (P-Chirality). This result clearly indicated the possibility of the interaction of the amino group on the ligand with the incoming nucleophile.Keywords
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