On the pathogenesis of IDDM
- 1 September 1994
- journal article
- other
- Published by Springer Nature in Diabetologia
- Vol. 37 (S2) , S82-S89
- https://doi.org/10.1007/bf00400830
Abstract
A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2− and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.Keywords
This publication has 65 references indexed in Scilit:
- Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB ratsFEBS Letters, 1993
- Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expressionEuropean Journal of Immunology, 1991
- Repetitive Exposure of Pancreatic Islets to Interleukin-1β. AnIn VitroModel of Pre-diabetes?Autoimmunity, 1991
- Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanismFEBS Letters, 1990
- Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell CloneScience, 1990
- Interleukin 1β Increases the Cytosolic Free Sodium Concentration in Isolated Rat Islets of LangerhansScandinavian Journal of Immunology, 1990
- Insulin‐secreting β‐cells possess specific receptors for interleukin‐1βFEBS Letters, 1990
- Cytokines as Immune Effector Molecules in Autoimmune Endocrine Diseases with Special Reference to Insulin-Dependent Diabetes MellitusAutoimmunity, 1989
- ULTRASTRUCTURAL STUDIES OF TIME‐COURSE AND CELLULAR SPECIFICITY OF INTERLEUKIN‐1 MEDIATED ISLET CYTOTOXICITYActa Pathologica Microbiologica Scandinavica Series C: Immunology, 1987
- Type I Diabetes MellitusNew England Journal of Medicine, 1986