Polyene antibiotics. VII. Carbon-13 nuclear magnetic resonance evidence for cyclic hemiketals in the polyene antibiotics amphotericin B, nystatin A1, tetrin A, tetrin B, lucensomycin, and pimaricin.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (10) , 1035-1042
- https://doi.org/10.7164/antibiotics.29.1035
Abstract
Carbon magnetic resonance establishes conclusively that 6 polyene macrolide antibiotics containing keto groups (the heptaene amphotericin B, the tetraene-diene nystatin A1 and the tetraenes tetrin A, tetrin B, pimaricin and lucensomycin) exist in the hemiketal form in solution. Their spectra all contain a hemiketal C''s absorption near 97 ppm but lack a keto C''s absorption near 210 ppm. The non-polyenic macrolide erythromycin exists in the keto form.This publication has 3 references indexed in Scilit:
- ISOLATION OF CRYSTALLINE TENNECETIN AND COMPARISON OF THIS ANTIBIOTIC WITH PIMARICIN1961
- PIMARICIN. I. OXIDATION AND HYDROLYSIS PRODUCTSJournal of the American Chemical Society, 1958
- ILOTYCIN, A NEW ANTIBIOTIC1952