Influence of previous diuretic intake on the humoral and hormonal profile of idiopathic oedema

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Abstract
Three groups of women underwent water loading tests: normal subjects, idiopathic edema patients who had taken no medication for at least 3 mo., and 2nd edema group with recent diuretic intake. Idiopathic edema in drug-free patients was characterized by an abnormal capillary permeability, lower basal protein values, a dramatic drop in urinary output in the upright position due to reduced glomerular filtration, enhanced reabsorption of Na and water and stimulation of aldosterone and antidiuretic hormone (AVP) secretions. In these idiopathic edema cases, osmolar AVP regulation was disrupted but AVP control by plasma volume was maintained. In the basal state, patients with recent diuretic intake were characterized by a gain in body weight and by depletion of plasma volume and plasma K. In these subjects, urinary output in the upright posture was as insufficient as in drug-free patients but was due to higher Na reabsorption. Renal insensitivity to AVP was also observed. Osmolar regulation and volume regulation of AVP were both disrupted in these cases with recent diuretic intake.