The Effect of Fluoride in Saliva on Remineralization of Dental Enamel in Humans

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Abstract
The aim of this study was to investigate the ‘remineralizing potential’ in the mouth at certain intervals after a topical fluoride treatment. Remineralization was studied by microhardness measurements of slightly demineralized bovine enamel slabs. 4 dental students were given a topical acidulated phosphate fluoride (APF) treatment and 2, 4, 8 and 16 h after the treatment, 8 slabs were inserted and carried for 48 h. During the study, the subjects avoided other types of fluoride exposure. The statistical analysis of the microhardness changes showed a significant rehardening of the control slabs indicating remineralization from saliva. Slabs inserted 2–4 h after the fluoride treatment showed highly increased remineralization as compared to the controls, whereas those inserted 8 and 16 h after the treatment did not differ from the controls. The data are related to the fluoride concentration in saliva at various periods after APF treatments.

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