Conformationally Constrained DNA Mimics: Synthesis of a Novel Cyclopropyl-Amide Linked Dimer

1 July 1996

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1996 (07) , 687-689
https://doi.org/10.1055/s-1996-5570

Abstract

Synthesis of a new conformationally constrained dimeric building-block containing a cyclopropyl-amide functionality is described. Potential application of this dimer for antisense oligonucleotides is discussed.

Keywords

ANTISENSE
CYCLOPROPYL NUCLEOSIDE
MICHAEL REACTION
AMIDE BACKBONE
SUGAR-BACKBONE CONFORMATION

This publication has 0 references indexed in Scilit: