MK386: a potent, selective inhibitor of the human type 1 5α-reductase
- 31 July 1996
- journal article
- Published by Elsevier in The Journal of Steroid Biochemistry and Molecular Biology
- Vol. 58 (4) , 377-384
- https://doi.org/10.1016/0960-0760(96)00050-7
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Activity of the Type 1 5α-Reductase Exhibits Regional Differences in Isolated Sebaceous Glands and Whole SkinJournal of Investigative Dermatology, 1995
- The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductaseSteroids, 1995
- 4,7.beta.-Dimethyl-4-azacholestan-3-one (MK-386) and Related 4-Azasteroids as Selective Inhibitors of Human Type 1 5.alpha.-ReductaseJournal of Medicinal Chemistry, 1994
- 17.beta.-(N-tert-Butylcarbamoyl)-4-aza-5.alpha.-androstan-1-en-3-one Is an Active Site-Directed Slow Time-Dependent Inhibitor of Human Steroid 5.alpha.-Reductase 1Biochemistry, 1994
- Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.Journal of Clinical Investigation, 1993
- Finasteride: A slow-binding 5.alpha.-reductase inhibitorBiochemistry, 1993
- Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductaseJournal of Medicinal Chemistry, 1993
- Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasiaJournal of Clinical Endocrinology & Metabolism, 1992
- Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers*Journal of Clinical Endocrinology & Metabolism, 1990
- Inhibitors of steroid 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acneTrends in Pharmacological Sciences, 1989