Tissue Effects of Lysolecithin Injected Subcutaneously in Mice.

Publisher Website
Google Scholar
Abstract
Summary A series of mice was injected subcutaneously with lysolecithin and the tissues examined at measured intervals. Within 10 minutes after injection, striking edema with necrosis of fat tissue was evident at the injection site. Subsequent changes included infiltration with neutrophil leukocytes and histiocytes and hyalinization and necrosis of muscle cells. Despite the marked edema and contrary to previous reports, vascular damage was not demonstrated by light microscopy. The production of lysolecithin could account for much of the local necrosis resulting from snakebite.

This publication has 0 references indexed in Scilit: