Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet

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Abstract
This article reviews recent studies that have characterized the isolated rat hepatocyte couplet as a primary unit of canalicular bile formation. This cell culture system is proving to be particularly useful for identifying primary canalicular choleretics and for elucidating mechanisms of canalicular bile formation by electrophysiologic, fluorescent, and quantitative microscopic techniques.

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