Structural model of the ATP‐binding domain of the F1‐β subunit based on analogy to the RecA protein
Open Access
- 29 August 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 351 (1) , 1-5
- https://doi.org/10.1016/0014-5793(94)00796-9
Abstract
In contrast to the previous topological model of the ATP binding domain of the F1‐ATPase β subunit based on analogies to those of ras p21 and adenylate kinase, a more consistent model can be constructed with the known structure of the recA protein as a reference. The secondary structure of the F1‐ATPase β subunit predicted from the primary structure agrees well with that of the recA protein. The topology includes a repetitive βαCβαβαβαβ structure where all β strands are parallel and surround the central αC helix above which bound ATP is located. Several residues thought to be located at catalytic site as reported in genetic and chemical labeling work can be consistently positioned in this model.Keywords
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