Effect of Tilorone HCI, an Oral Interferon-Inducer, on Leukopoiesis in Rats

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Abstract
Single oral doses of 100 mg/kg T to rats caused marked lymphopenia. Recovery started after 12 h and was accompanied by depletion of small lymphocytes in lymph follicles of the spleen and the appearance of young lymphocytes with vacuoles and basophil granules in smears of lymph nodes and spleen. Abnormal mononuclear cells whose protoplasm often contained vacuoles and basophil granules appeared in the blood after 48 h. They disappeared in the course of 2–3 weeks. The granulocytic system responded to T with a short-lasting leukocytosis, a shift to left and appearance of basophil granules in neutrophil and eosinophil promyelocytes and myelocytes. Repeated administration of T caused only minor hematologic changes. No other organs were affected by the drug.

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