Development and Evaluation of a New Water-Soluble lodinated Myelographic Contrast Medium with Markedly Reduced Convulsive Effects

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Abstract
A new water-soluble myelographic contrast agent with more hydrophilic properties than metrizamide was developed and tested in the primate (Macaca mulatta) and the cat. A new animal model that allows study of convulsive effects of intrathecally administered contrast agents in the awake monkey was designed. With this sensitive model the new contrast agent apparently had a remarkably reduced convulsive effect when compared with metrizamide and other media. Intrathecal hypertonic solutions in the cat depressed evoked cortico-spinal responses, whereas neurotoxic effects of the iodinated water-soluble contrast media increased them. The net effect was a combination of the 2 actions.

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