Ototoxicity of Ethacrynic Acid and Aminoglycoside Antibiotics in Uremia
- 29 May 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 280 (22) , 1223-1224
- https://doi.org/10.1056/nejm196905292802208
Abstract
THE ototoxic effects of aminoglycosides such as streptomycin, kanamycin and neomycin are well established. Since renal failure increases the hazard of ototoxicity from these drugs, it can be expected that, in the presence of azotemia and delayed drug excretion, other agents thought to be minimally ototoxic may exhibit an enhanced capacity for this adverse effect.1 Before the report of Schneider and Becker2 ethacrynic acid was not considered an ototoxic drug. They described the induction of acute transient hearing loss by ethacrynic acid in five patients with marked impairment of renal function.Others3 4 5 6 have alluded to single cases of similar effects. . . .Keywords
This publication has 8 references indexed in Scilit:
- TRANSIENT AND PERMANENT DEAFNESS FOLLOWING TREATMENT WITH ETHACRYNIC ACID IN RENAL FAILUREThe Lancet, 1969
- TOXICITY OF KANAMYCIN IN ADULTSAnnals of the New York Academy of Sciences, 1966
- ABSORPTION, DISTRIBUTION, EXCRETION AND FATE OF KANAMYCINAnnals of the New York Academy of Sciences, 1966
- Acute transient hearing loss after ethacrynic acid therapyArchives of internal medicine (1960), 1966
- The ototoxicity of kanamycin: A comparative histopathological studyThe Laryngoscope, 1965
- Studies on Ethacrynic Acid in Patients with Refractory EdemaAnnals of Internal Medicine, 1965
- Neomycin Ototoxicity: Report of a Case Due to Rectal and Colonic IrrigationsJAMA Otolaryngology–Head & Neck Surgery, 1964
- DIHYDROSTREPTOMYCIN DEAFNESSJAMA, 1959