Tallysomycin, a new antitumor antibiotic complex related to bleomycin. III. Antitumor activity of tallysomycins A and B.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (7) , 667-674
- https://doi.org/10.7164/antibiotics.31.667
Abstract
The antitumor activity of tallysomycins A and B was determined in 5 experimental tumor systems in mice. Tallysomycins A and B were highly active against B16 melanoma, sarcoma 180 ascites tumor and Lewis lung carcinoma, and moderately active against P388 leukemia but were without effect on lymphoid leukemia L1210. The antitumor activity of tallysomycin A was 2-3 times that of tallysomycin B and 3-17 times that of bleomycin. Tallysomycin A was about 1.5 and 4 times more toxic for mice than tallysomycin B and bleomycin, respectively, in terms of subacute LD50 values.This publication has 2 references indexed in Scilit:
- Tallysomycin, a new antitumor antibiotic complex related to bleomycin. II. Structure determination of tallysomycins A and B.The Journal of Antibiotics, 1977
- Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.The Journal of Antibiotics, 1977