11-Oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, an orally active antiallergy agent

31 December 1978

journal article
research article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 22 (1) , 114-116
https://doi.org/10.1021/jm00187a026

Abstract

A new series of 11-oxo-11H-pyrido[2,1-.beta.]quinazolinecarboxylic acids and related analog was synthesized and evaluated as potential antiallergy agents. In the rat PCA [passive cutaneous anaphylaxis] test, 11-oxo-11H-pyrido[2,1-.beta.]quinazoline-8-carboxylic acid is orally active and more potent than cromolyn sodium or doxantrazole intravenously.