IMMUNOLOGICAL MEMORY FOR MICROBIAL ANTIGENS IN LYMPHOCYTES OBTAINED FROM HUMAN BRONCHIAL-MUCOSA

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Abstract
Memory for previous immunologic contact with microbial antigens was detected in lymphocytes from human bronchi as a secondary immune response, when tested in vitro. Antigens stimulated a predominantly proliferative response in blood lymphocytes that was significantly greater than the response in mucosal lymphocytes with purified protein derivative and Herpes-simplex type I antigens. Co-culture experiments with autologous blood lymphocytes showed that cell-dependent suppression was 1 mechanism of the low response of bronchial lymphocytes. In the patient who inhaled a foreign body, a proliferative response to antigens was restricted to bronchus-associated lymphoid tissue lymphocytes, suggesting a recruitment of antigen-reactive cells from a circulating pool.

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