Synthesis of an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Carbapenem via Stannatrane-Mediated Stille Coupling
- 30 March 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (8) , 1081-1084
- https://doi.org/10.1021/ol005641d
Abstract
A short synthesis of carbapenem 1 is described. The key step involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon. This cross-couping, which allows the introduction of the complete side chain in one step, utilizes a stannatrane as the heteroalkyl transfer reagent.Keywords
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