Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
- 15 January 2003
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 166 (2) , 156-162
- https://doi.org/10.1007/s00213-002-1329-2
Abstract
Marijuana has been reported to suppress nausea produced by chemotherapy treatment in human cancer patients. Although there is abundant evidence that cannabinoid agonists attenuate vomiting in emetic species, there has been little experimental evidence of their anti-nausea potential. Considerable evidence suggests that conditioned rejection reactions in rats reflect nausea. The present experiments evaluated the potential of low doses of the cannabinoid agonists, Δ-9-tetrahydrocannabinol (THC; 0.5 mg/kg, i.p.), and HU-210 (0.001 mg/kg and 0.01 mg/kg, i.p.), and the CB1 antagonist SR-141716A in modulating the establishment and the expression of lithium-induced conditioned rejection reactions in rats.Keywords
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