The effects of polyoxyethylene compounds on the hydrolysis of chlorbutol
- 1 October 1966
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 18 (10) , 640-648
- https://doi.org/10.1111/j.2042-7158.1966.tb07777.x
Abstract
The rates of hydrolysis of chlorbutol are reduced by surface-active agents, but not by polyethylene glycols. The ratio of the rate-constant in simple aqueous systems to that in systems containing surface-active agents can be predicted if the distribution coefficient for chlorbutol between the micellar pseudo-phase and the aqueous phase is known and is independent of concentration.Keywords
This publication has 4 references indexed in Scilit:
- The solubilisation and inactivation of preservatives by non-ionic detergentsJournal of Pharmacy and Pharmacology, 1964
- Interaction of Some Pharmaceuticals With Macromolecules IJournal of Pharmaceutical Sciences, 1964
- The Kinetics of Degradation of Chlorobutanol**State University of Iowa, College of Pharmacy, Iowa CityJournal of the American Pharmaceutical Association (Scientific ed.), 1959
- Interaction of Preservatives with Macromolecules I.Journal of the American Pharmaceutical Association (Scientific ed.), 1958