Toxicity and Sterilization Effectiveness of Aflatoxins B1 and G1 and Distribution of Aflatoxin B1-14C in House Flies12

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Abstract
Aflatoxins B1 and G1were administered orally to adult Musca Domestica L., and their effects on sterility and morality were determined. He ring-labeled aflatoxin B1 also was fed to study the distribution of the ingested compound in the tissues. Aflatoxin C1 was more toxic and more effective as a sterilant than aflatoxin B1. In contrast, aflatoxin B1 has been reported to be more toxic to ducklings and some other animals. Aflatoxin G1 was more toxic to male than to female flies, whereas B1 was equally toxic 10 males and females. Both aflatoxin compounds were temporary sterilants. The amount of 14C present in the haemolymph, fat bodies, ovaries, testes, and heads was measured for 3 days after oral administration of aflatoxin B1-14C. At the end of 3 days, the amount of 14C had decreased in the head, haemolymph and fat bodies, In the ovaries, however, the amount of 14C had increased markedly, while it remained relativity constant in the testes during the 3 days. The accumulation of aflatoxin B1-14C or its metabolites in the Ovaries may account for the temporary chemosterilant effect.

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