THE EFFECT OF LOCAL BLOOD-FLOW ON THE HEALING OF EXPERIMENTAL INTESTINAL ANASTOMOSES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 154  (5) , 657-661
Abstract
Using dogs, devascularized areas were experimentally produced in the small intestine and colon. Quantitative measurements of the submucosal local blood flow using the H2 clearance method were taken. In the area slightly toward the ischemic side of the devascularized margin, the local blood flow was less on the mesenteric side in both the ileum and the colon and microcirculation was better maintained in the colon than in the ileum. When the anastomosis was performed in the area in which the local blood flow on the mesenteric side was 60% of the control value in the ileum or 70% in the colon, recovery of the control value was achieved by the 7th postoperative day. When anastomosis was performed in the area in which the local blood flow on the mesenteric side was 15% of the control value in the ileum and 22% of the control value in the colon, the flow on the mesenteric side did not recover to the level of the control value by the 7th postoperative day and anastomotic leakage occurred in some dogs. All anastomotic leakage occurred on the mesenteric side. The local blood flow rate at the point at which the last signal was detected by Doppler ultrasound flowmeter, after moving the Doppler probe from the devascularized margin toward the ischemic side, was 57% of the control value in the ileum and 54% of that in the colon. Such levels of blood flow are considered sufficient for successful healing of tissue after an anastomosis.

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