The liver in siblings of patients with Indian childhood cirrhosis: a light and electron microscopic study.
Open Access
- 1 April 1981
- Vol. 22 (4) , 295-300
- https://doi.org/10.1136/gut.22.4.295
Abstract
Liver biopsies from 29 siblings of patients with Indian childhood cirrhosis (ICC) and from two age-matched controls were examined by routine light and transmission electron microscopy. Histochemical stainings for copper and copper-binding protein were also carried out. The mild and non-specific structural alterations that were observed did not differ from those seen in control livers, even though a slight to moderate excess of copper and copper-binding protein was demonstrated in the majority. Aggregates of microtubules seen in some siblings, as well as in control livers, may indicate the preconditions for development of Mallory hyaline. It is possible that these features suggest a susceptibility for the development of ICC but not early disease.This publication has 20 references indexed in Scilit:
- CYTOPLASMIC COPPER AND ITS TOXIC EFFECTSThe Lancet, 1979
- Biochemistry and Physiology of MicrotubulesAnnual Review of Biochemistry, 1976
- Griseofulvin interacts with microtubules both in vivo and in vitroJournal of Molecular Biology, 1976
- Localization of hepatitis B surface antigen in conventional paraffin sections of the liver. Comparison of immunofluorescence, immunoperoxidase, and orcein staining methods with regard to their specificity and reliability as antigen marker.1975
- Indian childhood cirrhosis.1975
- Histopathological evolution of Indian childhood cirrhosis with emphasis on criteria of early diagnosis.1974
- An epidemiologic approach to Indian childhood cirrhosis.1973
- Morphologic variants of alcoholic hyalin.1972
- Epidemiologic survey of Indian childhood cirrhosis.1972
- The normal human liver cell. Cytochemical and ultrastructural studies.1971