THE EFFECT OF CHEMOTHERAPY ON THE RETENTION OF METHYLENEDIPHOSPHONATE-TC-99M BY THE OSTEOGENIC-SARCOMA OF THE MOUSE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 19  (4) , 200-205
Abstract
The cytostatic action of adriblastine on the accumulation of 99mTc-MDP [methylenedisphosponate] by a transplantable osteogenic sarcoma in the mouse was investigated. The quantitative determination of the activity concentration in the tumor showed a concentration value 8 days after the administration of the cytostatic which was nearly twice that found in the untreated animals, as clearly observed in scintigrams obtained with a .gamma.-camera using a pinhole-collimator. The histoautoradiography showed a higher concentration of the radiopharmaceutical which can be attributed to higher ossification within the tumor due to the application of the cytostatic agent. Scintigraphy with 99mTc-MDP apparently is a good follow-up method during treatment with cytostatics.

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